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Parkinson's Disease. (Photo compliments of Drs. E.C. Alvord, Jr., and A. E. Spence, Dept. of Pathology, University of Washington). Parkinson's disease involves degeneration of neurons of the substantia nigra, and is characterized by resting tremor, rigidity and bradykinesia. Compare the substantia nigra in both the normal and Parkinson's midbrain slabs. Microscopically, there is a depopulation of pigmented nigral neurons in Parkinsonism, with a concomitant decrease in the dopaminergic projection to the striatum.

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Software (C) 1997 <---> Images (C) 2000